Severe hypomagnesemia and hypoparathyroidism induced by omeprazole.

Please cite this article as: Rodríguez Ortega P, et al. Hipomagnesemia grave e hipoparatiroidismo secundario a omeprazol. Endocrinol Nutr. 2013;60:156--7. causes include nutritional problems and gastrointestinal or renal losses, while isolated malabsorption is a less common cause. In the past year, alerts related to chronic administration of proton pump inhibitors (PPIs) have increasingly been reported. Renal response to increased gastrointestinal losses of this cation is the maintenance of a FEMg less than 2%, and severe hypomagnesemia per se impairs PTH secretion, leading to hypokalemia in most cases. We report the case of a male patient who experienced severe hypomagnesemia and hypokalemia secondary to chronic diarrhea. He had been treated with omeprazole for 10 years. The side effect of this drug, uncommon but with significant clinical consequences and whose etiology has not been fully elucidated yet, has prompted us to report this causal relationship in the scientific literature. Diagnosis is confirmed by the reversibility of electrolyte disorders upon drug discontinuation once other causes have been ruled out, which occurred in our patient. 156 CARTAS CIENTÍFICAS